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Basic CBD knowledge at BuyLegalMeds.com
CBD (cannabidiol) is a non-intoxicating component of the cannabis plant with enormous therapeutic potential. Although CBD does not make people feel high, it is causing quite a buzz among scientists. In addition, it also affects health professionals, and medical marijuana patients who are using CBD-rich products to treat a wide range of conditions. Such as chronic pain, cancer, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, antibiotic-resistant infections, multiple sclerosis, schizophrenia etc..
Academic research centers in the USA and elsewhere are currently studying the effects of CBD on these ailments. Scientists refer to CBD as a “promiscuous” compound because it confers therapeutic benefits in many different ways. While tapping into how we function physiologically and biologically on a deep level. Likewise, extensive preclinical research and some clinical studies have shown that CBD has strong qualities. Such as anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-psychotic, anti-tumoral, and neuroprotective. Furthermore, Cannabidiol can change gene expression and remove beta amyloid plaque, the hallmark of Alzheimer’s, from brain cells.
Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years. But how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. For now, the scientific literature has identified more than 65 molecular targets of CBD.
Although CBD has little binding affinity for either of the two cannabinoid receptors, namely CB1 and CB2. However, CBD also acts through various receptor-independent pathways. For example, by delaying the “reuptake” of endogenous neurotransmitters. And enhancing or inhibiting the binding action of certain G-protein coupled receptors.
Here are some of the ways that CBD confers its manifold therapeutic effects.
Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London. They have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes. And it includes (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.
5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages. And they are to produce either an excitatory or inhibitory response, depending on the chemical context of the message.
CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant. Also it has a strong affinity for the 5-HT1A receptor (even more so than CBD). Apart from that, preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC. And they also have anti-nausea properties.
CBD directly interacts with various ion channels to confer a therapeutic effect. CBD. For example, binds to TRPV1 receptors, which also function as ion channels. Because TRPV1 is known to mediate pain perception, inflammation and body temperature.
For one thing, TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.”. For another, TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants or subfamilies. And they mediate the effects of a wide range of medicinal herbs.
Scientists also refer to TRPV1 as a “vanilloid receptor,” named after the flavorful vanilla bean. As for Vanilla, it contains eugenol, an essential oil that has antiseptic and analgesic properties. Besides, it helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.
The Function of CBD Products at BuyLegalMeds.com
CBD AS A REUPTAKE INHIBITOR
How does CBD, an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein (FABP). And it chaperones various lipid molecules into the cell’s interior. Second, these intracellular transport molecules also escort tetrahydrocannabinol (THC) and the marijuana-like molecules, the endocannabinoids anandamide and 2AG. And they are across the membrane to several targets within the cell. Third, CBD and THC both modulate receptors on the surface of the nucleus, which regulate gene expression and mitochondrial activity.
Cannabidiol, it turns out, has a strong affinity for three kinds of FABPs, and CBD competes with our endocannabinoids. And they are fatty acids, for the same transport molecules. Once it is inside the cell, anandamide is broken down by FAAH [fatty acid amide hydrolase], a metabolic enzyme. And it is as part of its natural molecular life cycle. But CBD interferes with this process by reducing anandamide’s access to FABP transport molecules. And it delays endocannabinoid passage into the cell’s interior.
THE EFFECTS OF CBD
According to a team of Stony Brook University scientists, CBD functions as an anandamide reuptake and breakdown inhibitor. Thereby it raises endocannabinoid levels in the brain’s synapses. Enhancing endocannabinod tone via reuptake inhibition may be a key mechanism whereby CBD confers neuroprotective effects against seizures. As well as many other health benefits.
CBD’s anti-inflammatory and anti-anxiety effects are in part attributable to its inhibition of adenosine reuptake. By delaying the reuptake of this neurotransmitter, CBD boosts adenosine levels in the brain, which regulates adenosine receptor activity. A1A and A2A adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. These receptors have broad anti-inflammatory effects throughout the body.
CBD AS THE ALLOSTERIC RECEPTOR MODULATOR
CBD also functions as an allosteric receptor modulator. So it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor.
Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity. For its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. However, the sedating effects of Valium and other Benzos are mediated by GABA receptor transmission. So CBD reduces anxiety by changing the shape of the GABA-A receptor in a way that amplifies the natural calming effect of GABA.
NEGATIVE ALLOSTERIC MODULATOR
Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor. And it is concentrated in the brain and central nervous system. While cannabidiol doesn’t bind to the CB1 receptor directly like THC does, CBDinteracts allosterically with CB1. And it changes the shape of the receptor in a way that weakens CB1’s ability to bind with THC.
As a negative allosteric modulator of the CB1receptor, CBD lowers the ceiling on THC’s psychoactivity. And that’s why people feel not as high when using CBD-rich cannabis compared to consuming THC-dominant medicine. Because a CBD-rich product with little THC can convey therapeutic benefits without having a euphoric or dysphoric effect.
Top 3 Best-Sellers at BuyLegalMeds.com
One. ACTIV8 CBD Tincture (325mg, 1,000mg and 2,500mg, 5,000mg and 10,000mg of CBD)
Price: $39.99 USD
Its highly medicated CBD Tincture (Peppermint Flavor) is a full spectrum CBD oil with terpenes. And fatty acids from the entire natural industrial hemp plant.
Each 1oz container contains up to 10k mg of CBD oil that is sublingual (drops under the tongue).
Hemp extract is an oil that is derived from the stalks and seeds of the industrial hemp plant. Besides, hemp is rich in CBD, also known as Cannabidiol. And CBD offers many health benefits without any serious side effects.
In 2014 Congress and President signed the Farm Bill to protect CBD product from industrial hemp. And it is legal for us to ship worldwide.
Two. Cloud N9ne CBD Gummies – Night Time – 20 Pack (10mg CBD per gummy)
Price: $29.99 USD
Its night time Cloud N9ne CBD Gummies use high quality ingredients with melatonin and natural flavors. To ensure freshness and quality, people carefully infuse all CBD Gummies with pure cannabinoids (CBD) .
Cloud N9ne night time Gummies come in many natural flavors and each Gummy comes with 10 mg of CBD oil.
- Eat two Cloud N9ne Night Time CBD Gummies (20 mg of CBD) each night after dinner.
- Dosage contains 2-4 Gummies a day depending on anxiety and stress levels.
- This product is for medicinal use only.
Three. Cloud N9ne CBD Flower – Strain: Cherry Wine
Price: $18.97 USD
Cloud N9ne CBD Flower (Strain: Cherry Wine). This product contains less than 0.3% Delta 9 THC and is non-psychoactive.
Ingredients: Hand-Trimmed Hemp CBD Flower
According to 7 U.S.C. §5940, industrial hemp means the plant Cannabis sativa L. and any part of such plant. So whether it grows or not, with a Delta-9 THC concentration of at most 0.3% on a dry weight basis. Only the Delta-9 THC level is relevant, not THC-A. As shown by the enclosed Certificate of Analysis on this page, this hemp flower has a Delta-9 THC level. And it is on a dry weight basis equal to 0%, well below the 0.3% maximum level. Therefore, this flower is hemp, not marijuana, and is perfectly legal to possess and sell. This right applies in any state pursuant to the Full Faith and Credit Clause, Article VI, Section 1 of the Constitution, the Supremacy Clause, Article VI, Section 2 of the Constitution, and the Equal Protection Clause, Section 1 of the Fourteenth Amendment.
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