1.What is depression?

Depression, also known as depressive disorder, is characterized by significant and persistent low mood and is the main type of mood disorder. Clinically, the depression is not commensurate with its situation. The depression of emotions can range from sullen to grief, inferiority and depression, and even pessimism. There may be suicide attempts or behaviors, even stupor; some cases have obvious anxiety and athletic agitation; In severe cases, psychotic symptoms such as hallucinations and delusions may occur. Each episode lasts for at least 2 weeks, and the elderly or even years. Most cases have a tendency to recurrent. Most of the episodes can be relieved, and some may have residual symptoms or become chronic.

2.Traditional treatments for depression

There are several treatments to treat depression, but it is not available for everyone. Different degrees of depression have different treatments on the basis of person, age, and physical conditions. We usually use or hear about these traditional depression treatments.

①Antidepressant medication

In brain, chemistry elements may lead to an individual’s depression and may be involved into treatment. Because of it, antidepressants might be used to alter someone’s brain chemistry. As we know, there are more than 25 species of antidepressants used in the market, all of which help to control the symptoms of depression. Because many drugs are at risk of addiction, there are still many people who have concerns about the use of these drugs.


Psychotherapy is mainly for individuals with mild depression that includes Self-help groups, Talking Therapy, Cognitive behavioral therapy (CBT), etc. Self help groups and talking therapy have the similar treatment methods, they both can relieve sorrow by chatting with members in the groups. But, It is worth mentioning that those therapies are just suitable for mild depressions. Psychotherapy may contains only individual, but it can involve others: such as, couples or family therapy can help remove the pessimism and close the relationship with partners or family members. And, again, it is useful for mild depression.

③Electroconvulsive Therapy

Electroconvulsive Therapy(ECT), also named electroshock therapy, is a medical and legal treatment mostly used for patients with major depressive disorder who had no evident response for standard treatments. While the patient is under common anesthesia, electrodes are placed on patient’s scalp and a specific current power ups.

ECT has been used since 1940s, but still are there some negative effects are involved in the unqualified staff, improper use of equipment, and incorrect operation. And the most vital one is the brave for a major depressive patient to walk on the operation table.

3.What is CBD?

Cannabis plants contain more than 100 different compounds called cannabinoids. They interact with the endogenous cannabinoid system of the human body.

One of the cannabinoids is CBD or cannabidiol (pronounced cann-a-bid-EYE-ol). The CBD is non-mental, and more and more research indicates that this cannabinoid has many health benefits.So far, the CBD is the most promising compound in marketing and medicine. Although it is not mentally active, many users think it can help them relax their nerves. Some people think that regular doses of CBD help to avoid Alzheimer’s disease and heart disease…
For more information(definition and benefits) about the CBD, please click on the link below.


4.How CBD helps with depression?

With quantity of depression grows, people urgently seeking for a safer and more efficient way to relieve the pain from depression. In the past few years, effective treatments on depression have been certified. And the treatment effects of CBD on depression is gradually being recognized by more and more people.

A 2010 study concluded that, “CBD induces antidepressant-like effects comparable to those of Imipramine. These effects of CBD were probably mediated by activation of 5-HT(1A) receptors.”

Web link: https://www.ncbi.nlm.nih.gov/pubmed/20002102

A 2011 stated, “In the last few years, there have been several advances in the determination of the role of the endocannabinoid system in the etiology of depression and the functional actions of antidepressant drugs. Specifically, a deficiency in endocannabinoid signaling is sufficient to produce a “depressive-like” phenotype at the preclinical level…and capable of inducing symptoms of depression in humans at a clinical level. Moreover, facilitation of endocannabinoid signaling is sufficient to produce all of the behavioral and biochemical effects of conventional antidepressant treatments.”

Web link: https://www.ncbi.nlm.nih.gov/pubmed/21111017

A 2016 study reported, “our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia.”

Web link: https://www.ncbi.nlm.nih.gov/pubmed/26711860

Another 2016 study concluded, “These findings extend the limited knowledge on the antidepressant effect of CBD, now shown for the first time in a genetic animal model of depression. These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.”

Web link: https://www.ncbi.nlm.nih.gov/pubmed/27010632

CBD has been used as a depression treatment for a long time. In 1620s, doctors in India used cannabis to treat their patients’ depression, at the same time, an English clergyman, Robert Burton, recommended the use of cannabis in his book The Anatomy of Melancholy.

5.How long will it take to feel the effects?

After learning about CBD’s effectiveness in depression, let’s talk about how long it takes to affect the depression after using the CBD. But before that, the particular methods and amounts will be involved below and we should know that different methods of use will cause different effects on its’ absorption and action. That is to say, for the same usage object, the CBD will be absorbed at different rate in the same amount, and we call it bioavailability.

Now let’s look at how long it takes for CBD to work when consumed with a particular method and the bioavailability of different application methods.

①Orally(intake by swallowing)

Obviously, this is a way that CBD needs to be absorbed through the gastrointestinal tract and metabolized by the liver.

The duration for effect happens: 30-180 minutes. It is the slowest way to show effect up, no matter you have a empty or full stomach, the age and physical condition are also factors which have influence on the absorption.

Bioavailability: We can see intake CBD by swallowing is the worst among the methods on the basis of its duration and taste, so it is not suggested by depression patients.

②Topically (absorption through the skin)

There is a difference between topical CBD and other methods, because the CBD is hardly get into bloodstreams, but just absorbed in skin, tissues and joints. However, the effect is received differently through the skin from that get into the blood and then exerts its effect on the body.
The duration for effect happens: 10-120 minutes. We need to know that if you want a better effect from topical intake, you’d better use it for a constant usage.

Bioavailability: It depends on the types of skin and the period of usage, it is also beneficial to depression if you use it continuously.

③Sublingually(under the tongue)

It is a way that put the CBD products under the tongue, when you are in a depression state, you juts need to drop it under your tongue, and the product can be absorbed into the blood and tissues via the mucous membrane.The duration for effect happens: 5-30 minutes. It depends on the person, age, and basic physical condition. And it is the second fastest way get the effect for the body.

Bioavailability: It is very suitable for depression patients, because it is a safety duration till the effect happens and it is not easily addictive.

④Pulmonary (directly intake to the lungs)

This is a way that CBD can get into lungs and blood directly by smoking and vaporization. This is the fastest way for CBD to get through the body.
The duration for effect happens: 30-600 seconds.

Bioavailability: When CBD is absorbed into the lung is the highest among those methods, that is to say, this way has the shortest duration and the fastest effect on action of CBD. But we do not suggest you use this method frequently, the fastest treatment needs highest tolerance of the body, it means the present effect is just present.

After analysis, we can have a clear recognize on how long it will take effects on depression treatment, but all that we need to know is that this will depend on a series of factors including the user’s physical condition, intolerance levels, the amount of the CBD and the form in which it’s used.

6.Is it addictive?

The answer is NO. Because of its raw material, marijuana, which a a strong-smelling plant from whose dried leaves a number of euphoriant and hallucinogenic drugs are prepared, many people have a misunderstanding on CBD. Unlike THC(tetrahydrocannabinol), there is no chance being addictive. There are more than 85 cannabinoids in cannabis plants, and THC is the only one that produces a powerful, intoxicating mental effect. While CBD doesn’t have those addictive properties and intoxicating effects.
To know more about THC, and make a good choice for CBD, please click below:


7.Scientific studies on CBD for depression

Scientists in Brazil researched and found that the patients who with social anxiety disorder(SAD) got a positive effect on CBD treatment.

According to the result, scientists declared that CBD significantly affects the anxiety of SAD patients, and they also found CBD’s effect actively in limbic and paralimbic areas in brain.

In Neuropsychopharmacology Journal, one of the studies on Naïve Social Phobia Patients – Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking proved that a single dose of CBD significantly decreased cognitive impairment, anxiety, and discomfort in patients’ speech behaviour, and reduced alert in their anticipatory speech. Due to the increasing persistence of CBD in the treatment of neuropsychiatric disorders, we hope to present another study that specializes in patients with anxiety disorders.

However, according to the researches, we know that mature treatments are still in the investigation, but we need to keep a positive attitude towards the CBD usage.

8.Current status of using CBD to treat depression

More and more researches have been finished on CBD. Now, it is considered as a medical miracle compound due to it increasing and successful rate on all types of mental illness.

For its treatment on depression, CBD has been found successfully available. Recently, there was a test on a number of mice (modified as a stand-in for tests with depression medicine). The results showed that the mice got a immediate improvement when treated with CBD. And after 30 minutes CBD treatment, the mice behaved a noticeable decreasing hyperactivity which is an obvious symptom as well as depression in humans.

Actually, the increasing number of CBD users who got rid of anxiety are demonstrated by scientific researches and they are telling their own stories now.

Among sufferers of anxiety, Shannon Donnelly is one of them who struggled with the disease and began a regimen of CBD pills. Compromised with suicidal depression and anxiousness every time she left the house, with an incorporation of CBD she felt panic attacks flushing out her body.
She described that “CBD has changed the way her brain works. She no longer catastrophizes day to day and religiously uses CBD for confidence that makes her feel better about all the situations, whether at work or personally.”

Another CBD user, Bradleigh Rivera told her CBD use process “how she was skeptical about CBD usage proved her wrong after she noticed visible flushing out the anxiolytic symptoms from her mind. Struggling with insomnia and anxiety since Bradleigh was only 7 years old, now enjoys her days with ease by CBD usage.”

In an online survey, Andrew Flit, a pain management chiropractor told that CBD oil has helped his anxiety and panic attacks remained. He has also started recommending CBD oil to his patients for back pain to keep them calm throughout the day.

So, finally, can CBD help with depression? Obviously, the answer is Yes.
Currently, CBD is legal in all the states of USA and some other countries can be obtained by any over the age of 18 person. However, please note that different states have different legal requirements and specific conditions for the CBD products. Know more about legalization about CBD, please click:



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