A new study shows that fat meals can enhance the body’s absorption of cannabidiol. Compared to products containing the Convention on Biological Diversity. The amount of CBD in the body after a high-fat meal is increased four-fold in the blood. The maximum is 14 times higher.



experiment procedure

To find out the effect of fat meals on CBD absorption, the team measured the CBD concentration of patients with epilepsy at the MINCEP Epilepsy Care Clinic, who took 99% of pure CBD capsules. The concentration of patients taking CBD and standardized fat breakfast (breakfast burritos) on an empty stomach was compared.

“The type of food can make the amount of CBD absorbed into the body very different. Although fatty foods can increase the absorption of CBD, it can also increase variability because not all diets contain the same amount of fat,” Pharmacy College and Research Co-author, Professor Angela Birnbaum said.

“The increased dose of CBD absorbed into the body can also reduce the cost of the drug,” said research co-author, Ilo Leppik, professor of medicine and adjunct professor at the School of Pharmacy.

The study conclusion:

  • CBD exposure is greatly increased when CBD is taken with high-fat foods;
  • Compared with fasting, the amount of CBD in the body increased by a factor of 4 compared with food, and the maximum amount of blood in the participants increased by 14 times.
  • No cognitive differences were found, which is consistent with previous studies.

“For patients with epilepsy, the goal is to maintain consistent plasma concentrations,” Birnbaum said. “This study suggests that CBD concentrations may vary greatly if patients take different approaches, sometimes with or without food. Changes in blood concentrations may make patients more susceptible to seizures.”

The study was funded by the American Epilepsy Foundation, the Patricia L. Nangle Foundation and a gift from a grateful family. Additional M research authors include Susan Marino, School of Pharmacy, Masonic Cancer Center; Christopher Barkley, School of Pharmacy; Rory Remmel, Masonic Cancer Center; Michaela Roslawski, School of Pharmacy; M Twins Student Ashwin Karanam; University of Minnesota doctor Aden Gramling.

Dr. Angela Birnbaum of FAES is a professor at the School of Pharmacy. Her research focuses on drug concentrations and response variability associated with older adults, pregnant women, children, and drug addiction. Dr. Birnbaum’s research includes investigations into epilepsy drugs, including medical cannabis.
Ilo Leppik, MD, is a professor at the School of Pharmacy and an epilepsy expert in epilepsy care at the University of Minnesota. His research focuses on neurology and epilepsy – especially in elderly patients with epilepsy, canine epilepsy persistence and cannabis treatment for epilepsy.

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Founded in 1892, the University of Minnesota School of Pharmacy is the only pharmacy school in Minnesota with campuses in Twin Cities and Duluth. The School of Pharmacy improves health through innovative education, pioneering research and interdisciplinary practice to meet the diverse needs of people in Minnesota and the world.


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